Organ or part of body involved: Spleen

Symptoms and indications: Enlarged spleen, which can be felt by palpating the abdomen. Other symptoms, depending on the cause.

Causes and risk factors: Some of the causes of splenomegaly include:
Cirrhosis of the liver - which can increase the blood pressure inside the vessels of the spleen.
Cystic fibrosis - a genetic disorder, characterised by excessive mucus production, particularly in the lungs and pancreas.
Cytomegalovirus - a common viral infection that causes mild, flu-like symptoms.
Glandular fever - an infection caused by the Epstein-Barr virus.
Haemolytic anaemias such as thalassaemia, a genetic disorder that affects the production of the oxygen-carrying protein in red blood cells (haemoglobin).
Hodgkin's disease - cancer of the lymphatic system.
Leukaemia - cancer of the bone marrow that affects the blood cells.
Lymphoma - cancer of the lymph nodes of the lymphatic system.
Malaria - a parasite transmitted to humans by the bite of infected mosquitoes.